Set in 1964, a three-day journey along Route 66 begins when Bobby Falls, a 19-year-old serial killer, hitches a ride with Jim Goodwin, a celebrity animal handler travelling with his precious cargo: his TV chimpanzee, Spanky.

When Bobby’s car breaks down in the desert while on the run from some of the bookies who have already taken two of his fingers, he becomes trapped in the nearby small town where the people are stranger than anyone he’s encountered. After becoming involved with a young married woman, her husband hires Bobby to kill her. Later, she hires Bobby to kill the husband.

Bobby Earl is facing the electric chair for the murder of a young girl. Eight years after the crime he calls in Paul Armstrong, a professor of law, to help prove his innocence. Armstrong quickly uncovers some overlooked evidence to present to the local police, but they aren’t interested – Bobby was their killer.

When Bobby accidentally kills his wife before a get together at their home, he stops at nothing to hide the evidence from the arriving guests, even if it means murder.

Bobby Bishop (Sheen) is a special assistant to the President of the United States. Accidentally, he meets his friend professor Pochenko on the street. Pochenko has time to tell Bishop about some conspiracy in the White House but then immediately gets killed by an assassin. Now bad guys are after Bobby as the only man who knows about a plot. Bishop must now not only survive, but to stop the conspirators from achieving their goal. And he doesn’t know whom to trust.